Transcatheter Closure of Atrial Septal Defects in Adults: Clinical Outcomes, Procedural Safety, and Long-Term Follow-Up

doi:N/A

Bangaldesh Journal of Cardivascular Medicine

2024, Volume 2, Issue 4 : 1-3

Research Article

Transcatheter Closure of Atrial Septal Defects in Adults: Clinical Outcomes, Procedural Safety, and Long-Term Follow-Up

Michael J. Anderson

Sarah K. Thompson

Ahmed R. Malik

Priya N. Sharma

⁴

Department of Cardiology, Heart and Vascular Institute, Boston, USA

Division of Structural Heart Disease, University Medical Center, London, UK

Department of Interventional Cardiology, International Cardiac Research Centre, Dubai, UAE

⁴

Department of Cardiovascular Medicine, Global Institute of Cardiac Sciences, New Delhi, India

Abstract

Background

Atrial Septal Defect (ASD) is one of the most common congenital heart defects identified in adults. Untreated ASD may result in right ventricular overload, atrial arrhythmias, pulmonary hypertension, heart failure, and paradoxical embolism. Transcatheter closure has emerged as the preferred treatment for suitable secundum ASDs due to its minimally invasive nature and excellent outcomes.

Objective

To evaluate procedural success, clinical outcomes, complications, and long-term follow-up results of transcatheter ASD closure in adult patients.

Methods

A prospective observational study was conducted involving 220 adult patients diagnosed with secundum ASD who underwent transcatheter closure between January 2018 and December 2024. Clinical, echocardiographic, procedural, and follow-up data were analyzed.

Results

Successful device implantation was achieved in 216 patients (98.2%). Mean ASD diameter was 19.4 ± 6.8 mm. Procedure-related complications occurred in 4.5% of patients. Significant reductions in right ventricular dimensions and pulmonary artery pressures were observed at 12 months. Symptomatic improvement occurred in 89.8% of patients. Residual shunting was observed in only 1.8% at one-year follow-up.

Conclusion

Transcatheter closure of ASD in adults is a safe and highly effective therapeutic strategy associated with excellent procedural success, low complication rates, and substantial improvement in cardiac remodeling and clinical symptoms.

Keywords

Atrial Septal Defect

Structural Heart Disease

Congenital Heart Disease

Septal Occluder Device

Interventional Cardiology

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