Background: Coronary artery disease is a major cause of heart failure, especially heart failure with reduced ejection fraction. Coronary revascularization may improve symptoms, ventricular function, hospitalization rates, and survival in selected patients.
Objective: To evaluate the role of coronary revascularization in improving clinical outcomes among patients with ischemic heart failure.
Methods: A prospective multicenter observational study included 680 patients with heart failure and significant coronary artery disease undergoing medical therapy, PCI, or CABG between January 2020 and December 2024. Outcomes included mortality, heart failure hospitalization, left ventricular ejection fraction improvement, functional status, and major adverse cardiovascular events.
Results: Revascularized patients showed greater improvement in angina, functional capacity, and left ventricular ejection fraction compared with medical therapy alone. CABG demonstrated stronger long-term survival benefit in patients with multivessel disease and severe LV dysfunction, while PCI was associated with faster symptom relief and lower early procedural burden.
Conclusion: Coronary revascularization plays an important role in selected patients with ischemic heart failure. Optimal benefit depends on coronary anatomy, myocardial viability, LV function, comorbidity burden, and Heart Team decision-making.