Predictors of No-Reflow Phenomenon Following Primary PCI

doi:N/A

Bangaldesh Journal of Cardivascular Medicine

2024, Volume 2, Issue 1 : 1-5

Research Article

Predictors of No-Reflow Phenomenon Following Primary PCI

James R. Mitchell

Sarah K. Ahmed

David L. Thompson

Department of Cardiology, Global Medical Research Institute, Boston, USA

Department of Internal Medicine, International Heart Research Center, London, UK

Department of Interventional Cardiology, European Institute of Cardiovascular Sciences, Berlin, Germany

Abstract

Abstract

The no-reflow phenomenon is a serious complication following primary percutaneous coronary intervention (PPCI) in patients presenting with ST-segment elevation myocardial infarction (STEMI). Despite successful reopening of the epicardial coronary artery, inadequate myocardial perfusion persists due to microvascular obstruction and tissue-level reperfusion failure. No-reflow is associated with larger infarct size, ventricular dysfunction, heart failure, arrhythmias, and increased mortality. Identifying predictors of no-reflow is critical for risk stratification and preventive interventions. This study reviews the pathophysiology, clinical significance, predictors, diagnostic approaches, and management strategies of no-reflow following primary PCI. Through extensive literature synthesis, a predictive framework is proposed to guide clinicians in identifying high-risk patients and improving procedural outcomes.

Keywords

No-Reflow Phenomenon

Primary PCI

STEMI

Coronary Microvascular Dysfunction

Reperfusion Injury

Myocardial Infarction

Predictors

Interventional Cardiology

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