Background: Ventricular septal defect (VSD) is among the most common congenital heart defects worldwide. While surgical closure has long been considered the gold standard treatment, percutaneous transcatheter closure has emerged as a less invasive alternative with favorable outcomes. The present study evaluates procedural success, safety profile, and mid-term outcomes following percutaneous VSD closure. Methods: A retrospective observational study was conducted involving 150 patients who underwent percutaneous VSD closure between January 2019 and December 2024. Clinical, echocardiographic, procedural, and follow-up data were analyzed. Primary outcomes included procedural success and complete defect closure. Secondary outcomes included complications, arrhythmias, residual shunts, and functional improvement. Results: The mean patient age was 11.8 ± 7.2 years. Procedural success was achieved in 146 patients (97.3%). Complete closure at 12 months was observed in 94.5% of patients. Significant reductions in left ventricular dimensions and pulmonary artery pressures were observed. Major complications occurred in 2.7% of patients, while transient arrhythmias occurred in 6.0%. No procedure-related mortality was reported. Conclusion: Percutaneous VSD closure demonstrates excellent procedural success and favorable clinical outcomes with low complication rates. It represents a safe and effective alternative to surgical repair in appropriately selected patients.