Percutaneous coronary intervention (PCI) has become a cornerstone in the management of coronary artery disease (CAD). Traditionally, PCI procedures have been guided primarily by coronary angiography; however, angiography provides only a two-dimensional representation of the vessel lumen and may underestimate plaque burden, vessel dimensions, and stent-related complications. Intravascular imaging modalities such as intravascular ultrasound (IVUS) and optical coherence tomography (OCT) offer detailed visualization of coronary anatomy and stent deployment characteristics. Recent evidence suggests that intravascular imaging-guided PCI may improve procedural outcomes and reduce adverse cardiovascular events. This review compares intravascular imaging-guided PCI and angiography-guided PCI, focusing on procedural optimization, clinical outcomes, stent performance, safety, cost-effectiveness, and future implications.